The two clubs have never met before in competitive rugby.
Saracens have won five in a row in Aviva Premiership Rugby since their opening weekend defeat to London Irish at Twickenham. Sarries have won six of their last seven home matches in the Premiership.
Exeter Chiefs have slipped to three successive Premiership defeats and are still to open their winning account away from home in Aviva Premiership Rugby.
Referee: Rob Debney (61st Premiership game)