Aviva Premiership Rugby champions Saracens have already qualified for a 4th semi-final appearance in the competition.
Saracens only loss in their last five Premiership matches was 19-24 to Harlequins at Wembley Stadium on 31 March. This game will be the 156th and last in the Premiership at Vicarage Road unless Sarries do not secure a home semi-final.
Exeter Chiefs realistically require a victory in this game to give themselves any chance of making the Aviva Premiership Rugby semi-finals for the first time. The Chiefs have won their last four away matches in the Premiership.
Saracens have already beaten Exeter twice this season: in the Premiership at Sandy Park and in the Anglo-Welsh Cup at Vicarage Road. The Chiefs only previous victory against Saracens came at Watford in October 2010.
Referee: Tim Wigglesworth (49th Premiership game)