The Saints have not achieved a Premiership double over the Sharks since season 19992000.
Sale Sharks have lost their last seven matches in all competitions – their poorest run since season 1999/2000.
The Sharks have gained just one league point from their last three outings in the Guinness Premiership, from their 16-22 defeat at Wasps on 14 February. Northampton Saints’ only defeat in their last eight matches in the Guinness Premiership was 6-13 at Harlequins on 20 February.
The teams have already met twice this season with Northampton winning both times: 21-16 at Franklin’s Gardens in the Guinness Premiership and 20-14 in the LV= Cup at Edgeley Park.