The two teams drew 16-all at Kingston Park in round two, whilst Newcastle have won on two of their last three visits to Edgeley Park.
Sale Sharks have won just two of their last 13 matches in all competitions since New Year’s Day. The Sharks have won two of their last three games at Edgeley Park, against Worcester and London Wasps.
Newcastle Falcons’ only victory in their last eleven encounters in all competitions was 25-13 at home to Gloucester in the Guinness Premiership on 31 March. The Falcons have won three times on the road in the Premiership this season: at Bath, London Irish and London Wasps.
Referee: Andrew Small (42nd Premiership game)