Wasps have lost on their last five visits to Edgeley Park since a 27-25 win on 25 March 2005.
Sale Sharks have slipped to eight successive defeats in all competitions. Four of those reversals have come at Edgeley Park, where Sale have not lost five in a row since moving to the venue in 2003.
London Wasps’ only loss in their last five matches in all competitions was 10-26 at Leeds Carnegie on 28 February. Wasps won 22-16 when the two teams clashed in the Guinness Premiership on 14 February, but have not completed a season’s double over the Sharks since 2003-04.
Referee: Chris White (173rd Premiership game)