Sale Sharks have won just one of their last four Aviva Premiership Rugby matches: 15-12 at home to Worcester on 10 February.
The Sharks’ only loss at Edgeley Park in their last five games in all competitions was 9-19 to Brive in the Amlin Challenge Cup on 19 January.
London Wasps have slipped to eight straight defeats in Aviva Premiership Rugby since their 14-12 victory at Worcester on 28 October.
Sale won 29-18 when the two teams met at Adams Park in round three; the Sharks have not achieved a seasons double over Wasps since 2008/09.
Referee: Sean Davey (106th Premiership game)