The Sharks have won just one of their last eight Premiership clashes with Irish: 14-8 at Edgeley Park on 9 January 2009.
Reebok Stadium in Bolton becomes the 30th different venue for Premiership Rugby, and hosts its first game of rugby union after six previous games of rugby league at the stadium.
Sale Sharks’ last four games have all been won by the home side on the day, whilst the Sharks are going for a third successive home win in the Premiership for the first time since season 2008/09.
The last eleven matches contested by London Irish have all been won by the home side on the day, whilst the Exiles have slipped to ten straight away defeats since they beat Exeter 12-9 at Sandy Park on 23 October.
Referee: JP Doyle (23rd Premiership game)
Live on ESPN HD.