Leeds have never beaten the Sharks in 17 previous attempts in all competitions.
Sale Sharks are in the midst of an unwanted run of five successive losses in all competitions, although the Sharks have not lost at home in the Guinness Premiership since London Irish were the visitors on 2 October.
Leeds Carnegie have slipped to four straight defeats in all competitions. Leeds have won just one of their last six matches in the Guinness Premiership, but have scored at least one league point in their last four games.
The two teams have already met twice this season with Sale victorious on both occasions in November: 27-3 in the LV= Cup at Edgeley Park and 24-17 at Headingley Carnegie in the Guinness Premiership.
Referee: Dave Pearson (137th Premiership game)