This game will be the third between the two sides in the last 20 days, with Sale winning both clashes in the European Cup in December. Quins have won just once at Edgeley Park: 19-13 in the Guinness Premiership on 19 November 2004.
Sale Sharks have slipped to back to back defeats in the Guinness Premiership, but at Edgeley Park the Sharks have won their last four matches in all competitions.
Harlequins have lost their last three games in all competitions since their 30-27 victory at Leeds in the Guinness Premiership on 4 December.
Referee: Chris White (168th Premiership game)
Live on Sky Sports HD