Harlequins have visited Edgeley Park on seven previous occasions in all competitions and won just once: 19-13 in the Premiership on 19 November 2004.
Sale Sharks have won just one of their last six games in the Premiership: 35-18 over Newcastle at Edgeley Park in round one.
Harlequins only win in their last five Premiership encounters was 35-20 at home to Sale on 8 May. Quins have not won away from home in the Premiership in 2010.
Referee: Dave Pearson (145th Premiership game)