Sale Sharks require just one match point to qualify for next season’s Heineken Cup. The Sharks have won successive Aviva Premiership Rugby matches against Bath and Gloucester.
Edgeley Park hosts it’s 99th and final Premiership game before Sale move to the City of Salford Stadium.
Harlequins have already reached a second Premiership semi-final but still require three points to guarantee that it will be played on home soil. Quins’ only away win so far in 2012 was 24-19 against Saracens at Wembley Stadium on 31 March.
The last seven clashes between the two clubs in the Premiership have all been won by the home side on the day. Quins have already won at Edgeley Park this season, with a 37-25 victory in the Anglo-Welsh Cup on 21 October. The Londoners only previous win at the venue in the Premiership came on 19 November 2004.
Referee: Martin Fox (79th Premiership game)