The last 15 fixtures between the two sides in all competitions have been won by the home side on the day, whilst Gloucester have never won in seven previous visits to Edgeley Park.
Sale Sharks have slipped to three straight defeats in Aviva Premiership Rugby and dropped from 8th to 10th place in the table.
The Sharks have lost their last two Premiership matches at Edgeley Park but have not lost three in a row in the competition at the venue since season 2006/07.
Gloucester Rugby’s only loss in their last six Premiership encounters was 6-12 at Newcastle in round 8, during those six games only table-topping Northampton have picked up more league points.
Referee: Wayne Barnes (88th Premiership game)
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