Sale Sharks only victory in the last four rounds of Aviva Premiership Rugby was 31-13 at Bristol on 30th October.
The Sharks have lost three of their last five home games in the competition.
Exeter Chiefs have won their last two Aviva Premiership Rugby encounters, at Newcastle and at home to Worcester, scoring twelve tries in the process.
The Chiefs have not won successive away games in the competition since December 2015.
The last four encounters between the two clubs have all gone in favour of the home team whilst Exeter’s only previous victory at AJ Bell Stadium was 18-16 in November 2013.
Sale Sharks v Exeter Chiefs (AJ Bell Stadium, 7.45pm)
Referee: Wayne Barnes (174th Premiership game).
Assistant Referees: Peter Allan & Paul Dix.
TMO: David Rose.
Live on BT Sport