The two clubs only previous competitive meeting was in round nine at Sandy Park where the home side won 24-19.
Sale Sharks have won two of their last four matches in all competitions. The Sharks have won their last two games at Edgeley Park against Leeds and Gloucester.
Exeter Chiefs have lost their last four encounters, and have won just once away from home since October: 23-13 at Newcastle on 18 February.
Referee: Peter Fitzgibbon (IRFU, 2nd Premiership game)