The last six clashes between the two clubs have been evenly split with three wins apiece, however Quins’ only win at Franklin’s Gardens since 1997 was 28-15 on 17 February 2007.
Northampton Saints’ impressive eleven game unbeaten run in all competitions continues despite their trip to Gloucester on Boxing Day falling foul of the weather.
The Premiership pacesetters are just one point clear of second placed Leicester with two games in hand. Saints have won all eight games they have played at Franklin’s Gardens this season.Harlequins have won their last three matches in all competitions.
Quins are winless in their last eleven away games in the Premiership since their 30-27 victory at Leeds on 4 December 2009.
Referee: Dean Richards (43rd Premiership game)