Newcastle Falcons have won just once in Aviva Premiership Rugby since round five: 26-25 at home to Gloucester on 2 December.
The Falcons have won five of their last seven encounters at Kingston Park in all competitions.
London Irish’s only win in their last five matches was 23-15 at home to Gloucester in the Anglo-Welsh Cup on 28 January.
The Exiles have won just once on the road since September: 34-14 at Racing Metro in the European Cup on 10 December.
The Falcons have won just one of their last 13 clashes with the Irish since February 2006: 15-11 at Madejski Stadium in the Premiership on 22 November 2009. London Irish have not lost at Kingston Park since 30 April 2005.
Referee: JP Doyle (37th Premiership game)