Newcastle have not beaten Quins since their 24-16 scoreline at Kingston Park in the Premiership on 15 March 2009.
Newcastle Falcons gained a vital first Aviva Premiership Rugby victory since November with their 22-5 win at Leeds on Sunday.
The Falcons’ only win in their last four matches at Kingston Park in all competitions was 17-3 over Exeter in the Anglo-Welsh Cup on 6 February.
Harlequins have lost two of their last three matches in the Premiership, whilst their solo win on the road in the tournament since December 2009 was 16-13 at Northampton on New Year’s Day 2011.
Harlequins have not won at Kingston Park in the Premiership since 10 November 2006.
Referee: Andrew Small (53rd Premiership game)