Saracens have won their last two fixtures with Wasps, but have lost on all six previous occasions they have visited Adams Park.
London Wasps have won back to back games at Newcastle in the LV= Cup and at home to Sale in the Guinness Premiership.
Saracens have won four of their last five matches in all competitions, and three of their last four on the road.
Sarries most recent victory on Wasps soil was 19-15 at Loftus Road in the Premiership on 19 October 1997.
Referee: Sean Davey (89th Premiership game)