Both matches between London Wasps and Harlequins this season will be played at Twickenham, whilst the rivals have shared the spoils from their last four encounters in the Guinness Premiership.
London Wasps have lost their opening Guinness Premiership game for the past two seasons. Wasps have won their last three matches in the Premiership since tripping up 14-22 at Bath on 1 April.
Harlequins have won their last two matches on the opening weekend of a new season, but have been victorious just once in their last four encounters in all competitions. Quins have lost only one of their last five games at Twickenham.
Referee: Dean Richards (22nd Premiership game)