London Irish have picked up just four league points from their last six Aviva Premiership Rugby matches – the poorest return of any side over that period.
The Exiles have won only one of their last four matches at Madejski Stadium in all competitions: 23-15 over Gloucester in the Anglo-Welsh Cup on 4 February.
Saracens have slipped to successive defeats against Harlequins in the Premiership and Clermont Auvergne in the European Cup but have not lost three in a row since March 2010. Sarries’ solo away defeat since November was 11-16 at Worcester in the Premiership on 24 February.
Saracens have won their last two games against London Irish but have not been victorious at Madejski Stadium since 23 March 2007.
Referee: Martin Fox (78th Premiership game)