Sale’s only victory over Irish in their last seven encounters was 14-8 at Edgeley Park on 9 January 2009. The Sharks’ most recent victory at Madejski Stadium was 31-14 on 15 October 2006.
London Irish top the Aviva Premiership Rugby table following four successive victories against Gloucester, Newcastle, Leeds and Exeter. The Exiles are unbeaten at home in any competition this season.
Sale Sharks have won their last three games in all competitions since their 24-25 reversal at home to Wasps on 1 October.
The Sharks have won their last two away matches in Padova and Leeds and are going for a third successive victory on the road in the same season for the first time since 2006/07.
Referee: Martin Fox (59th Premiership game)