London Irish’s last four games in Aviva Premiership Rugby have all been won by the home side on the day, however the Exiles have won just two of their last five matches at Madejski Stadium in all competitions.
Sale Sharks’ four game winning run ended at Leicester on New Year’s Day. The Sharks’ only away win in the Premiership since round three was 16-13 at Bath on 3 December.
Sale won 30-29 at Edgeley Park when the two sides met in round two, and are going for a first season’s double over the Exiles since 2005/06.
Referee: Wayne Barnes (101st Premiership game)