London Irish have lost their last two Aviva Premiership Rugby matches 7-37 at Exeter and 7-36 at Sale.
The Exiles have won their last three matches at Madejski Stadium since Jersey beat them there in the semi-final of last year’s British & Irish Cup.
Northampton Saint have lost only one of their last four Aviva Premiership Rugby matches: 24-55 to Saracens at Twickenham in the London double header.
The Saints have lost their last three away games in the competition.
The East Midlanders’ only loss in their last seven encounters with London Irish in Premiership Rugby was 23-25 on their most recent visit to Reading on Boxing Day 2015.
(Madejski Stadium, 3pm)
Referee: Luke Pearce (64th Premiership game).
Assistant Referees: Jack Makepeace, Greg Macdonald. TMO: Sean Davey.
Citing Officer: Nick Wood.