London Irish have already beaten the Saints at Reading this season: 37-20 in the Anglo-Welsh Cup on 30 January. Northampton have however won their last four Premiership matches with the Exiles.
London Irish have won their last three matches in Aviva Premiership Rugby, and have won six in succession at Madejski Stadium in all competitions.
Northampton Saints visit Gloucester on Tuesday evening.
Referee: David Rose (87th Premiership game)
Live on SkySports HD.