London Irish have won just one of their last five games: 23-15 against Gloucester – the only one of those which was played at home.
The Exiles only loss at Madejski Stadium in Aviva Premiership Rugby in their last six games was 12-13 to Bath in round seven.
Northampton Saints have won four of their last five games in Aviva Premiership Rugby, but have lost their last two away games in all competitions – at Bath and Gloucester.
London Irish beat Northampton 14-13 at Franklin’s Gardens in round three and have never before achieved a league double over the Saints.
Referee: Andrew Small (66th Premiership game)