Harlequins, who won 28-18 when the two teams met in round 11, are attempting a first Premiership double over London Irish since season 2002/03.
London Irish’s only win in their last eight Aviva Premiership Rugby encounters was 23-14 at home to Newcastle on 12 February. The Exiles have won their last three matches at Madejski Stadium in all competitions.
Harlequins have suffered just one defeat in their last eleven games in all competitions: 6-20 at Exeter in the Premiership on 12 February. ‘Quins have won just once on the road in the Premiership since December 2009 – 16-13 at Northampton on New Year’s Day.
‘Quins have won on two of their last three visits to Madejski Stadium in all competitions.
Referee: Sean Davey (96th Premiership game)