London Irish have lost just four of their last 14 Premiership encounters with Harlequins, whilst the Exiles have not beaten Harlequins at Twickenham since 2006.
London Irish concluded Aviva Premiership Rugby last season with a pair of defeats to Northampton and Leicester. The Exiles have won just one of their last five visits to Twickenham in all competitions: 33-16 over Saracens in last year’s London Double Header.
Harlequins, the reigning European Challenge Cup holders, won three of their last four matches in all competitions at the end of last campaign. Quins ended a four game losing run at “HQ” with their 28-18 victory over London Irish on 27 December.
Referee: Greg Garner (19th Premiership game)
Live on ESPN HD.