Leicester have won five of their last six encounters with London Irish, whilst the Exiles only previous victory of any sort at Welford Road since they first visited in 1923 was in the Premiership in May 2003.
Defending Premiership champions, Leicester Tigers have reached the playoffs for a seventh successive season. The Tigers have lost just one of their last 14 Aviva Premiership Rugby encounters.
London Irish slipped up 20-26 at home to Northampton Saints last time out, but won their most recent away match, 34-20 against Sale at the Reebok Stadium in Bolton on 16 April.
Referee: Greg Garner (18th Premiership game)