Leeds beat Saracens 19-12 at Headingley on 7 March to end an eight game losing run against the "Fez boys" in all competitions since 2004.
Leeds Carnegie have not won any Premiership matches in rounds 1, 2 and 3 since beating Rotherham in season 2003/04. Leeds have won just one of their last three encounters at Headingley Carnegie: 12-10 against relegated Worcester Warriors on 25 April.
Saracens have won their last four away games played at regular club grounds since Gloucester defeated them 29-28 at Kingsholm on 3 April.
Saracens have won on five of their last six visits to Headingley.
Referee: Sean Davey (91st Premiership game)