Leeds achieved a Premiership double over Wasps for the first time ever last season, whilst Wasps have won on six of their last seven visits to Headingley.
Leeds Carnegie continue to be winless in Aviva Premiership Rugby since round 21 last season. Their most recent victory at Headingley Carnegie was 12-10 against Worcester Warriors on 25 April.
London Wasps suffered their worst home defeat since 2004 when Northampton visited Adams Park on Sunday, however Wasps won their most recent away game in the Premiership 25-24 at Sale on 1 October.
Referee: Dean Richards (40th Premiership game)