Harlequins got back to winning ways against London Irish on Saturday following three successive defeats.
'Quins have not lost at Twickenham Stoop in Aviva Premiership Rugby since Saracens were the visitors in round 22 last season.
Worcester Warriors tripped up narrowly at Sale last Friday and have now lost their last three away matches since beating Wasps 6-0 at Adams Park in the Premiership on New Year’s Day.
Harlequins only two previous defeats to the Warriors in the Premiership both came in 2004/05 – Worcester’s inaugural season in the top-flight.
Referee: David Rose (97th Premiership game)