Sale have won their last four encounters with Harlequins in all competitions, since the Sharks won 38-20 in this equivalent fixture at The Stoop last season.
Harlequins occupy 8th place in the Guinness Premiership table and have lost their last two games in the competition: to Saracens and Leicester. Quins are unbeaten in their last seven Premiership matches at the Twickenham Stoop, since Saracens won there in September.
Sale Sharks preserved their Guinness Premiership status last weekend despite losing their last three games in the competition. The Sharks’ only away victory in the Premiership since January 2009 was at Leeds in November 2009.