Harlequins have won both of their home games so far this season, but have been defeated in all three on their travels. ‘Quins have lost just once in their last five encounters at Twickenham Stoop in all competitions, 24-62 to Exeter in the final game of last season.
Northampton Saints doubled their tally of victories in the 2016/17 Aviva Premiership Rugby campaign with their 20-19 win over Exeter at Franklins Gardens on Friday. The Saints have been victorious in two of their last three away games.
Northampton have won the last seven of their encounters with Harlequins in all tournaments since the Londoners 22-19 win at the Stoop in Aviva Premiership Rugby in May 2013.
Twickenham Stoop, 3pm – Live on BT Sport
Referee: Ian Tempest (22nd Premiership game). Assistant Referees: Paul Burton & Ross Campbell .TMO: David Sainsbury.