Harlequins are unbeaten in their last four clashes with Newcastle in all competitions, whilst the Falcons have not won at The Stoop since a 20-18 victory on 30 September 2000.
Harlequins opened their winning account in Aviva Premiership Rugby in style on Saturday with a maximum point victory over promoted Exeter Chiefs at the Twickenham Stoop. Quins’ only defeat in their last ten Premiership encounters at The Stoop was to Northampton on 11 September.
Newcastle Falcons have won just one game so far: 29-17 at home to London Wasps on 10 September. The Falcons have won only once on their travels in the Premiership since early January: 32-30 at Sale on 23 April.
Referee: Rob Debney (61st Premiership game)
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