Harlequins have not beaten Wasps since November 2008, although the two clubs did draw 29-all at Twickenham in round one of Aviva Premiership Rugby.
Harlequins have won their last four games in all competitions and on Sunday became the first team this season to defeat Northampton on their own patch. Quins’ only home loss since February 2010 was 16-20 to Northampton on 11 September.
London Wasps have lost just one of their last eight matches in all competitions: 6-13 against Saracens at Wembley Stadium on Boxing Day.
Referee: Wayne Barnes (88th Premiership game)