London Irish have won on their last three visits to the Twickenham Stoop, one of their old home grounds.
Harlequins are unbeaten in their last three fixtures in the Guinness Premiership since their 9-22 home defeat by table topping Saracens on 19 September. ‘Quins have won just one of their last five matches at the Stoop: 13-11 over Bath on 3 October.
London Irish’s only defeat in their last seven encounters in all competitions was 25-27 at home to Scarlets in the European Cup on 17 October. The Exiles have won their last five games on opposition soil.
Referee: George Clancy (IRFU, 1st Premiership game)