Harlequins only win in their last six Premiership meetings with London Irish was 14-9 at Madejski Stadium on 14 February 2009. The two clubs have met three times before at Twickenham with London Irish winning two of those.
Harlequins have won three of their last four games in all competitions, but in Aviva Premiership Rugby have won just once in their last five matches. Quins are winless in their last four visits to Twickenham, a sequence that has included two draws.
London Irish have slipped to seven successive defeats in all competitions – the Exiles’ worst run since 2002. Irish have already been victorious at Twickenham this season having beaten Saracens there, 33-16, in round one.
Referee: Andrew Small (50th Premiership game)
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