Quins have not beaten the Tigers in their last dozen meetings in all competitions since a 26-23 victory at the Twickenham Stoop in the Wildcard semi-final first leg on 14 May 2003.
Harlequins have lost four of their last five games in all competitions, but the Londoners only home reversal in the Guinness Premiership in their last ten matches was last season’s Premiership semi-final, 0-17 to London Irish.
Leicester Tigers lost 12-15 at Sale Sharks last Friday and in 24 seasons of league rugby have never begun a season with successive defeats. The Tigers have been defeated in two of their last three away matches.
Referee: Dave Pearson (128th Premiership game)