Harlequins have already won at Welford Road this season with a 34-25 scoreline there in the Anglo-Welsh Cup two weeks ago, but the Londoners have never won at the venue in the Premiership.
Leicester Tigers have lost their last four games in all competitions – their worst run since 2003/04, but in the Premiership have lost just one of their last 25 home games.
Harlequins’ only loss in their last five matches was 26-33 at Gloucester in Aviva Premiership Rugby on 23 October. Quins have not won away from home in the Premiership since a trip to Leeds on 4 December 2009.
Referee: Wayne Barnes (87th Premiership game)
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