Harlequins have already qualified for the semi-finals, and if they prevent Tigers winning this game it will be at home, whilst their only reversal in their last seven Aviva Premiership Rugby matches was 23-29 at Gloucester in round 16.
Leicester Tigers have picked up maximum points from their last five Premiership matches and require just two further league points to reach the playoffs for the eighth successive season. Tigers have suffered just one defeat to an English side since Harlequins visited Welford Road on 8 October.
In 27 previous encounters between the two clubs Harlequins have won just twice – in October and 17-9 at Twickenham Stoop on 19 April 2003. Harlequins have never managed a league double over Leicester in the same season.