After toppling one unbeaten side in Saracens last weekend, Harlequins travel to the Ricoh Arena on Sunday looking to do the same against Wasps in what is sure to be a pulsating encounter.
And with 103 Aviva Premiership Rugby matches already under his belt, veteran referee Greg Garner is the perfect man to cast his eye over such a crucial early-season clash.
The league’s other centurion referee, JP Doyle, has a West County derby on his hands in his 120th Aviva Premiership game in charge as Gloucester Rugby host Bath Rugby at Kingsholm.
Elsewhere, Matthew Carley will move just one game away from his 50th at Franklin’s Gardens where Northampton Saints welcome Exeter Chiefs.
Ian Tempest will take charge of Bristol Rugby and Saracens under the Friday night lights, Leicester Tigers trip to Sale Sharks will see Craig Maxwell-Keys at the helm, and Sunday’s final encounter between Worcester Warriors and Newcastle Falcons will be refereed by Tom Foley.
Match Officials for this weekend’s Aviva Premiership Rugby
Friday September 30:
Bristol Rugby v Saracens (Ashton Gate, 7.45pm)
Referee: Ian Tempest (21st Premiership game)
Assistant Referees: Jonathan Healy & Paul Burton
TMO: Stuart Terheege
Northampton Saints v Exeter Chiefs (Franklin’s Gardens, 7.45pm – Live on BT Sport)
Referee: Matthew Carley (49th Premiership game)
Assistant Referees: Gareth Copsey & Simon McConnell
TMO: Graham Hughes
Saturday October 1:
Sale Sharks v Leicester Tigers (AJ Bell Stadium, 2.30pm)
Referee: Craig Maxwell-Keys (22nd Premiership game)
Assistant Referees: Wayne Falla & Peter Allan
TMO: Geoff Warren
Gloucester Rugby v Bath Rugby (Kingsholm, 3pm – Live on BT Sport)
Referee: JP Doyle (120th Premiership game)
Assistant Referees: Ross Campbell & Roy Maybank
TMO: David Grashoff
Sunday October 2:
Wasps v Harlequins (Ricoh Arena, 2.30pm)
Referee: Greg Garner (104th Premiership game)
Assistant Referees: John Meredith & Nigel Carrick
TMO: Trevor Fisher
Worcester Warriors v Newcastle Falcons (Sixways, 3pm – Live on BT Sport)
Referee: Tom Foley (24th Premiership game)
Assistant Referees: Phillip Watters & Kelvin Stewart
TMO: Keith Lewis