Gloucester Rugby are able to call upon the quartet of players who have been on RBS Six Nations duty in recent weeks as they welcome Northampton Saints to Kingsholm for the latest round of Aviva Premiership action.
Returning to the starting line up are Billy Twelvetrees, Greig Laidlaw and Richard Hibbard in addition to Jonny May who was available for the Wasps fixture last week.
Also coming in to the starting line up to take on the Saints are full back Steve McColl and number eight Gareth Evans.
It's a game of some significance for Gloucester who are looking to maintain and improve upon a good run of form in 2015, whilst it will also be a good marker of progress made since the first meeting between the two sides at Franklin's Gardens on the opening day of the season.
Head Coach Laurie Fisher, talking to the local media this week, admitted it was good to have more selection options this week ahead of a tough game.
"We've got Richard, Greig and Billy back and we had Jonny back last week. Particularly with the long term injuries we have, it's good to be able to call upon those guys.
"They're wonderful professionals and have immediately got their heads into Gloucester Rugby and what's required to get a performance on Saturday. They provide good leadership around the place, there's been a good vibe and they've been integral to a good week's training.
"We were disappointed with last week, but that's a game that can't be won and the game that can be won is the next one.
"They're the defending champions and runaway leaders at the moment. It's going to be tough whatever way you look at it and that requires 100% of your attention.
"But it really is about focusing on our game. I don't think you can look too hard at Northampton, you know what they'll bring. If you shut down one component of their game, they can switch to attacking you somewhere else. So we need to get our motivation, energy levels, execution and understanding of our game right.”
Steve McColl; Charlie Sharples, Bill Meakes, Billy Twelvetrees (capt), Jonny May; James Hook, Greig Laidlaw; Dan Murphy, Richard Hibbard, John Afoa; Tom Savage, Tom Palmer; Sione Kalamafoni, Matt Kvesic, Gareth Evans
Darren Dawidiuk, Yann Thomas, Sila Puafisi, Elliott Stooke, Ross Moriarty, Dan Robson, Billy Burns, Henry Purdy