England Head Coach Eddie Jones has named an unchanged side for Saturday’s RBS 6 Nations game against Wales at Twickenham (4.00pm, live on ITV).
Second-row forward Maro Itoje keeps his place with fit-again Joe Launchbury among the replacements.
Joe Marler will start at loose-head prop ahead of Mako Vunipola while Ben Youngs gets the nod at scrum-half.
Centre Manu Tuilagi is named as a replacement having returned to fitness, along with Elliot Daly and Danny Care.
“Manu Tuilagi’s selection to the match day squad is based more on potential than his recent performances in the Premiership," said Jones. "He has trained well this week and I am pleased with what I’ve seen."
Luke Cowan-Dickie will be England's replacement hooker following the injury to Jamie George with Dylan Hartley leading England at Twickenham.
“It is a shame that Jamie George misses out through injury and we wish him well in his recovery, but it provides a great opportunity for Luke Cowan-Dickie to show what he’s about," explained Jones.
Saturday's game is likely to decide the destination of the 2016 RBS 6 Nations with both sides unbeaten in the tournament.
“We’ve picked our best 23 to get the job done on Saturday," said Jones. "The squad have prepared well this week and I’m happy with how things have progressed."
George Ford is chosen at fly-half with inside centre Owen Farrell partnering Jonathan Joseph.
Prop Kieran Brookes replaces Paul Hill in the matchday squad and flanker Jack Clifford makes up England's replacements.
“It was a tight call between Kieran Brookes and Paul Hill, who have pushed each other hard, but Kieran gets the nod for Saturday," added Jones.
“There is a huge amount to play for on Saturday and we are looking forward to being back at home in front of a vocal Twickenham crowd.”
ENGLAND TEAM TO FACE WALES:
1 Joe Marler (Harlequins, 40 caps)
2 Dylan Hartley (captain, Northampton Saints, 69 caps)
3 Dan Cole (Leicester Tigers, 59 caps)
4 Maro Itoje (Saracens, 2 caps)
5 George Kruis (Saracens, 13 caps)
6 Chris Robshaw (Harlequins, 46 caps)
7 James Haskell (Wasps, 65 caps)
8 Billy Vunipola (vice captain, Saracens, 24 caps)
9 Ben Youngs (Leicester Tigers, 55 caps)
10 George Ford (Bath Rugby, 20 caps)
11 Jack Nowell (Exeter Chiefs, 13 caps)
12 Owen Farrell (vice captain, Saracens, 38 caps)
13 Jonathan Joseph (Bath Rugby, 19 caps)
14 Anthony Watson (Bath Rugby, 18 caps)
15 Mike Brown (vice captain, Harlequins, 46 caps)
16 Luke Cowan-Dickie (Exeter Chiefs, 1 cap)
17 Mako Vunipola (Saracens, 30 caps)
18 Kieran Brookes (Northampton Saints 15 caps)
19 Joe Launchbury (Wasps, 30 caps)
20 Jack Clifford (Harlequins, 3 caps)
21 Danny Care (Harlequins, 56 caps)
22 Manu Tuilagi (Leicester Tigers, 25 caps)
23 Elliot Daly (Wasps, 1 cap)