London Welsh are the visitors to Kingsholm on Saturday (kick off 3pm) and scrum-half Callum Braley will make his first start in the Aviva Premiership while Henry Trinder makes his first start since September.
20 year old Braley has featured regularly in the first team squad this season and made starts in both the LV= Cup and European Rugby Challenge Cup. But Saturday will be his first Aviva Premiership start.
Meanwhile, having got 20 minutes under his belt as a replacement at Leicester Tigers last Friday, Henry Trinder will start a Premiership game for the first time since September 13th. He will partner Bill Meakes in the Gloucester midfield.
They are two of the five changes to the Gloucester starting line up from the one that took the field against the Leicester Tigers at Welford Road last weekend.
The other three are all up front. Aleki Lutui comes in for Darren Dawidiuk at hooker, while James Hudson gets the nod to partner Tom Savage in the boiler room. Meanwhile, Ross Moriarty replaces Gareth Evans in the back row.
The visitors come to Kingsholm without a competitive win so far this season, but Director of Rugby David Humphreys insists that the squad have taken nothing for granted.
"We've prepared this week in exactly the same way as we did for Leicester last weekend. We've made sure that the players know what to expect from London Welsh, but also fully understanding how we need to play.
"When you're playing teams below you in the league, who haven't had a good season, there's the temptation not to prepare in the same way you would normally. But we've done everything the same to ensure that we'll be ready to go, physically and mentally, when we hit the pitch on Saturday.”
And, despite having won at the Kassam Stadium twice this season, once in the Premiership and once in the LV= Cup, he stresses that both wins were hard fought.
"There's no doubt that in the two games we've played against them already this season, particularly the first one, the scoreline didn't reflect how close the game was.
"For us, it's a case this week of going out with a very clear plan of what we want to do. It's not about trying to win the game in the first minute, it's about building pressure and taking chances as they come along. As opportunities arise, you have to be in a position to take them.”
Billy Burns; Charlie Sharples, Henry Trinder, Bill Meakes, Henry Purdy; James Hook, Callum Braley; Dan Murphy, Aleki Lutui, John Afoa; Tom Savage (capt), James Hudson; Ross Moriarty, Matt Kvesic, Sione Kalamafoni
Darren Dawidiuk, Yann Thomas, Sila Puafisi, Elliott Stooke, Gareth Evans, Dan Robson, Mark Atkinson, Jacob Rowan