Tom Savage and Freddie Burns wear different numbered shirts to last weekend while, starting having been selected as replacements at the Madejski, are Dan Murphy, Rupert Harden, Will James, Ben Morgan and Rob Cook.
Gloucester made it three wins from three in the Amlin Challenge Cup this season with the win over the Exiles last weekend. A win on Saturday would strengthen their hold on pool one, but Davies insists that nothing is being taken for granted.
"It's a job that's only half done at the moment. It was great to come back the way we did last weekend against Irish, but they showed what a dangerous team they are and what they're capable of.
"We really weren't at the races in the first half last weekend, which was a bit disappointing. We've been like that a couple of times this season and have to guard against that.
"But it's a great opportunity for us, we've got ourselves into a very strong position and we're really looking forward to Saturday's game."
Rob Cook; Charlie Sharples, Mike Tindall, Billy Twelvetrees, Shane Monahan; Freddie Burns, Jimmy Cowan; Dan Murphy, Darren Dawidiuk, Rupert Harden; Will James, Jim Hamilton (capt); Tom Savage, Akapusi Qera, Ben Morgan
Koree Britton, Nick Wood, Shaun Knight, Sione Kalamafoni, Matt Cox, Dan Robson, Tim Molenaar, Martyn Thomas