Captain Jonathan Mills has recovered from the facial injury he sustained last Sunday to again lead the side.
On the bench, Dan Williamson replaces Alfie To'oala, who picked up a knock in training, while scrum half cover is provided by Nick Runciman, who replaces Jonah Holmes.
Welsh will line up with two former Sharks in their starting XV, in hooker Neil Briggs and Hills.
Briggs joined Sale in 2005 from Rotherham Titans and spent six seasons at the club before leaving to join Bourgoin in 2011. Hills came through the Sale Academy before establishing himself in the first-team squad. He joined Welsh from Sale in 2009 and will make his 73rd appearance for the Exiles on Friday.
London Welsh: 15. Tom Arscott, 14. Phil Mackenzie*, 13. Sonny Parker*, 12. Hudson Tonga'uiha*, 11. Nick Scott, 10. Gordon Ross*, 9. Tyson Keats, 1. Frank Montanella*, 2. Neil Briggs, 3. Paulica Ion*, 4 Jonathan Mills ©, 5. Matt Corker, 6. Daniel Browne, 7. Michael Hills, 8. Ed Jackson.
Replacements: 16. Dan George, 17. Tom Bristow, 18. Arthur Joly, 19. Kirill Kulemin*, Ed Williamson, 21. Nick Runciman, 22. Ryan Davis#, 23. Seb Jewell.
* Denotes full international
# Subject to RFU registration