Sarries have won on five of their last six visits to Twickenham in all tournaments, the loss being to Toulon in last season's European Cup semi-final.
Saracens have appeared in two previous Premiership finals, both against Leicester, losing in 2010 but becoming champions a year later.
Northampton Saints are bidding to become the eighth different side to become Champions of England, and the first after London Wasps in 2003 to attain a Premiership and European Challenge Cup double.
The last side to defeat the Saints in the Premiership was Saracens at Allianz Park on 13th April.
Coincidently, in the last 36 Premiership games the only time that Northampton have failed to register a try was also against Sale at Salford, on 22nd March.
The Saints only two victories in seven previous finals played at Twickenham came against Munster in the European Cup in 2000 and against Exeter in the National Trophy in 2008.
Saracens 28-24 victory in the Premiership at Allianz Park on 13th April ended a four game losing run to the Saints in all tournaments.
This is the first occasion that the two clubs have met at Twickenham, and also the first time they have met in any final, however they have clashed in eight previous quarter-finals or semi-finals in tournaments, with Saracens winning just twice, both at Franklin's Gardens, in the Tetley's Bitter Cup semi-final in 1998 and the Premiership semi-final in 2010.
On Saturday 31 May, at Twickenham Stadium, 3pm.
Referee: JP Doyle (80th Premiership game).
Assistant Referees: Wayne Barnes & Paul Dix. TMO: Graham Hughes.
Live on BT Sport