| Date | Time | Competition | Home |
| Away | Venue | TV / Att |
|
|---|
| Fri 11th Nov 11 | 20:00 | HC-P6 | Harlequins | 25 - 17 | Connacht Rugby | Twickenham Stoop | 11,866 | Report |
| Sat 12th Nov 11 | 13:30 | HC-P2 | London Irish | 19 - 20 | Edinburgh Rugby | Madejski Stadium | 6,712 | Report |
| Sat 12th Nov 11 | 14:30 | HC-P4 | Aironi Rugby | 12 - 28 | Leicester Tigers | Stadio Brianteo | 8,151 | Report |
| Sat 12th Nov 11 | 18:00 | HC-P1 | Munster Rugby | 23 - 21 | Northampton Saints | Thomond Park Stadium | 26,500 | Report |
| Sun 13th Nov 11 | 12:45 | HC-P3 | Glasgow Warriors | 26 - 21 | Bath Rugby | Firhill Stadium | 4,208 | Report |
| Sun 13th Nov 11 | 15:00 | HC-P5 | Saracens | 42 - 17 | Benetton Treviso | Vicarage Road | 5,077 | Report |
| Sun 13th Nov 11 | 16:00 | HC-P6 | Toulouse | 21 - 17 | Gloucester Rugby | Stade Ernest Wallon | 18,500 | Report |
| Fri 18th Nov 11 | 20:00 | HC-P2 | Cardiff Blues | 24 - 18 | London Irish | Cardiff City Stadium | 10,358 | Report |
| Fri 18th Nov 11 | 20:00 | HC-P1 | Northampton Saints | 23 - 28 | Scarlets | Franklin's Gardens | 13,475 | Report |
| Sat 19th Nov 11 | 14:30 | HC-P5 | Biarritz Olympique Pays Basque | 15 - 10 | Saracens | P d Sports Aguilera | 9,782 | Report |
| Sat 19th Nov 11 | 15:40 | HC-P6 | Gloucester Rugby | 9 - 28 | Harlequins | Kingsholm | 12,320 | Report |
| Sat 19th Nov 11 | 18:00 | HC-P4 | Leicester Tigers | 20 - 9 | Ulster Rugby | Welford Road | 21,473 | Report |
| Sun 20th Nov 11 | 15:00 | HC-P3 | Bath Rugby | 16 - 13 | Montpellier | Recreation Ground | 11,785 | Report |
| Fri 9th Dec 11 | 20:00 | HC-P6 | Harlequins | 10 - 21 | Toulouse | Twickenham Stoop | 14,282 | Report |
| Sat 10th Dec 11 | 13:30 | HC-P6 | Connacht Rugby | 10 - 14 | Gloucester Rugby | Sportsground | 5,115 | Report |
| Sat 10th Dec 11 | 14:30 | HC-P1 | Castres Olympique | 41 - 22 | Northampton Saints | Stade J-P Antoine | 8,954 | Report |
| Sat 10th Dec 11 | 16:40 | HC-P2 | Racing Métro 92 | 14 - 34 | London Irish | Stade Colombes | 8,112 | Report |
| Sat 10th Dec 11 | 18:00 | HC-P5 | Saracens | 31 - 26 | Ospreys | Wembley Stadium | 41,063 | Report |
| Sun 11th Dec 11 | 12:45 | HC-P3 | Bath Rugby | 13 - 18 | Leinster Rugby | Recreation Ground | 12,200 | Report |
| Sun 11th Dec 11 | 16:00 | HC-P4 | ASM Clermont Auvergne | 30 - 12 | Leicester Tigers | Std Marcel Michelin | 18,000 | Report |
| Fri 16th Dec 11 | 20:00 | HC-P5 | Ospreys | 13 - 16 | Saracens | Liberty Stadium | 7,098 | Report |
| Sat 17th Dec 11 | 13:30 | HC-P4 | Leicester Tigers | 23 - 19 | ASM Clermont Auvergne | Welford Road | 20,202 | Report |
| Sat 17th Dec 11 | 15:00 | HC-P2 | London Irish | 19 - 25 | Racing Métro 92 | Madejski Stadium | 7,011 | Report |
| Sat 17th Dec 11 | 15:40 | HC-P6 | Gloucester Rugby | 23 - 19 | Connacht Rugby | Kingsholm | 10,786 | Report |
| Sat 17th Dec 11 | 18:00 | HC-P3 | Leinster Rugby | 52 - 27 | Bath Rugby | AVIVA Stadium | 46,365 | Report |
| Sun 18th Dec 11 | 15:00 | HC-P1 | Northampton Saints | 45 - 0 | Castres Olympique | Franklin's Gardens | 11,670 | Report |
| Sun 18th Dec 11 | 16:00 | HC-P6 | Toulouse | 24 - 31 | Harlequins | Stade Toulouse | 32,000 | Report |
| Fri 13th Jan 12 | 20:00 | HC-P4 | Ulster Rugby | 41 - 7 | Leicester Tigers | Ravenhill | 11,900 | Report |
| Sat 14th Jan 12 | 13:30 | HC-P1 | Scarlets | 17 - 29 | Northampton Saints | Parc y Scarlets | 9,869 | Report |
| Sat 14th Jan 12 | 14:00 | HC-P3 | Montpellier | 24 - 22 | Bath Rugby | TBA | 10,106 | Report |
| Sat 14th Jan 12 | 15:40 | HC-P2 | London Irish | 15 - 22 | Cardiff Blues | Madejski Stadium | 9,923 | Report |
| Sat 14th Jan 12 | 18:00 | HC-P6 | Harlequins | 20 - 14 | Gloucester Rugby | Twickenham Stoop | 12,772 | Report |
| Sun 15th Jan 12 | 15:00 | HC-P5 | Saracens | 20 - 16 | Biarritz Olympique Pays Basque | Vicarage Road | 6,789 | Report |
| Fri 20th Jan 12 | 20:00 | HC-P6 | Connacht Rugby | 9 - 8 | Harlequins | Sportsground | 5,420 | Report |
| Fri 20th Jan 12 | 20:00 | HC-P6 | Gloucester Rugby | 34 - 24 | Toulouse | Kingsholm | 13,077 | Report |
| Sat 21st Jan 12 | 13:30 | HC-P3 | Bath Rugby | 23 - 18 | Glasgow Warriors | Recreation Ground | 11,015 | Report |
| Sat 21st Jan 12 | 15:40 | HC-P4 | Leicester Tigers | 33 - 6 | Aironi Rugby | Welford Road | 19,652 | Report |
| Sat 21st Jan 12 | 18:00 | HC-P1 | Northampton Saints | 36 - 51 | Munster Rugby | stadiummk | 22,220 | Report |
| Sun 22nd Jan 12 | 14:00 | HC-P5 | Benetton Treviso | 20 - 26 | Saracens | Stadio di Monigo | 4,500 | Report |
| Sun 22nd Jan 12 | 15:15 | HC-P2 | Edinburgh Rugby | 34 - 11 | London Irish | Murrayfield | 10,892 | Report |
| Sun 8th Apr 12 | 16:30 | HC-QF | Saracens | v | ASM Clermont Auvergne | Vicarage Road | Sky/FR2 | More |
|
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