| Date | Time | Competition | Home |
| Away | Venue | TV / Att |
|
| Thu 10th Nov 11 | 19:45 | ECC-P1 | Worcester Warriors | 14 - 23 | Stade Francais Paris | Sixways | 8,121 | Report |
| Fri 11th Nov 11 | 19:00 | ECC-P4 | Perpignan | 15 - 12 | Exeter Chiefs | Aime Giral | 11,336 | Report |
| Sat 12th Nov 11 | 15:00 | ECC-P2 | Newcastle Falcons | 27 - 19 | Lyon Rugby | Kingston Park | 3,533 | Report |
| Sat 12th Nov 11 | 18:30 | ECC-P5 | Brive | 26 - 18 | Sale Sharks | Parc Municipal | 5,500 | Report |
| Sat 12th Nov 11 | 20:55 | ECC-P3 | Bordeaux-Begles | 14 - 47 | London Wasps | Stade Andre Moga | 16,953 | Report |
| Fri 18th Nov 11 | 19:45 | ECC-P5 | Sale Sharks | 59 - 6 | Rugby Club La Vila | Edgeley Park | 4,910 | Report |
| Sat 19th Nov 11 | 15:00 | ECC-P4 | Exeter Chiefs | 68 - 0 | I Cavalieri Prato | Sandy Park | 5,937 | More |
| Sat 19th Nov 11 | 15:00 | ECC-P2 | Petrarca Padova | 3 - 34 | Newcastle Falcons | Stadio Plebiscito | 1,900 | Report |
| Sat 19th Nov 11 | 20:30 | ECC-P1 | Banca Monte Crociati | 3 - 34 | Worcester Warriors | Stadio XXV Aprile, Parma | 300 | Report |
| Sun 20th Nov 11 | 15:00 | ECC-P3 | London Wasps | 38 - 7 | Femi-CZ VEA Rovigo | Adams Park | 4,225 | Report |
| Thu 8th Dec 11 | 19:45 | ECC-P2 | Newcastle Falcons | 6 - 3 | Toulon | Kingston Park | 5,579 | Report |
| Thu 8th Dec 11 | 20:30 | ECC-P5 | Agen | 14 - 29 | Sale Sharks | Stade Armandie | 3,117 | Report |
| Sat 10th Dec 11 | 20:55 | ECC-P3 | Bayonne | 19 - 11 | London Wasps | Stade Jean Dauger | 11,876 | Report |
| Sun 11th Dec 11 | 15:00 | ECC-P1 | Bucharest Wolves | 13 - 24 | Worcester Warriors | Arcul de Triumf | 2,000 | Report |
| Sun 11th Dec 11 | 17:45 | ECC-P4 | Exeter Chiefs | 18 - 6 | Newport Gwent Dragons | Sandy Park | 5,944 | Report |
| Thu 15th Dec 11 | 19:45 | ECC-P3 | London Wasps | 25 - 11 | Bayonne | Adams Park | 4,350 | Report |
| Sat 17th Dec 11 | 15:00 | ECC-P1 | Worcester Warriors | 57 - 13 | Bucharest Wolves | Sixways | 6,703 | Report |
| Sat 17th Dec 11 | 20:55 | ECC-P2 | Toulon | 36 - 10 | Newcastle Falcons | Stade Mayol | 13,264 | Report |
| Sun 18th Dec 11 | 15:00 | ECC-P5 | Sale Sharks | 41 - 21 | Agen | Edgeley Park | 4,915 | Report |
| Sun 18th Dec 11 | 17:45 | ECC-P4 | Newport Gwent Dragons | 19 - 23 | Exeter Chiefs | Rodney Parade | 5,137 | Report |
| Sat 14th Jan 12 | 14:30 | ECC-P4 | I Cavalieri Prato | 10 - 50 | Exeter Chiefs | TBA | 1,050 | Report |
| Sat 14th Jan 12 | 15:00 | ECC-P3 | Femi-CZ VEA Rovigo | 11 - 32 | London Wasps | Mario Battaglini | 1,200 | Report |
| Sat 14th Jan 12 | 15:00 | ECC-P1 | Worcester Warriors | 57 - 10 | Banca Monte Crociati | Sixways | 4,531 | Report |
| Sat 14th Jan 12 | 16:00 | ECC-P5 | Rugby Club La Vila | 10 - 69 | Sale Sharks | TBA | 2,000 | Report |
| Sun 15th Jan 12 | 15:30 | ECC-P2 | Newcastle Falcons | 43 - 0 | Petrarca Padova | Kingston Park | 2,831 | Report |
| Thu 19th Jan 12 | 19:45 | ECC-P5 | Sale Sharks | 9 - 19 | Brive | Edgeley Park | 6,955 | Report |
| Sat 21st Jan 12 | 15:00 | ECC-P4 | Exeter Chiefs | 31 - 14 | Perpignan | Sandy Park | 7,966 | Report |
| Sat 21st Jan 12 | 15:00 | ECC-P2 | Lyon Rugby | 21 - 13 | Newcastle Falcons | TBA | 7,115 | Report |
| Sat 21st Jan 12 | 20:45 | ECC-P1 | Stade Francais Paris | 33 - 10 | Worcester Warriors | Stade Charlety | 6,693 | Report |
| Sun 22nd Jan 12 | 15:00 | ECC-P3 | London Wasps | 36 - 13 | Bordeaux-Begles | Adams Park | 4,809 | Report |
| Thu 5th Apr 12 | 20:45 | ECC-QF | Stade Francais Paris | v | Exeter Chiefs | Stade Charlety | Eurosp/Sky | More |
| Fri 6th Apr 12 | 20:45 | ECC-QF | Toulon | v | Harlequins | Stade Mayol | FR4/Sky | More |
| Sat 7th Apr 12 | 12:30 | ECC-QF | London Wasps | v | Biarritz Olympique Pays Basque | Adams Park | Sky/EurospFR | More |
|